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Trees within the order Fagales possess particularly potent allergens, e.g. the prototypical Bet v 1, the major white birch (Betula 1️⃣ verrucosa - now called B. pendula) pollen antigen. Bet v 1 is the main cause of type I allergies observed 1️⃣ in early spring. Type I, or immunoglobulin E-mediated (IgE-mediated) allergies affect 1 in 5 people in Europe and North America. 1️⃣ Commonly observed symptoms are hay fever, dermatitis, asthma and, in severe cases, anaphylactic shock. First contact with these allergens results 1️⃣ in sensitisation; subsequent contact produces a cross-linking reaction of IgE on mast cells and concomitant release of histamine. The inevitable 1️⃣ symptoms of an allergic reaction ensue.
Categorization [ edit ]
A nomenclature system has been established for antigens (allergens) that cause IgE-mediated 1️⃣ atopic allergies in humans.[2] This nomenclature system is defined by a designation that is composed of the first three letters 1️⃣ of the genus; a space; the first letter of the species name; a space and an Arabic number. In the 1️⃣ event that two species names have identical designations, they are discriminated from one another by adding one or more letters 1️⃣ (as necessary) to each species designation.
The allergens in this family include allergens with the following designations: Bet v 1, Dau 1️⃣ c 1, and Pru a 1. Other proteins belonging to this family include the major pollen allergens:
Structure [ edit ]
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